Her father was George Spencer, Duke of Marlborough, (26 January 1739 – 29 January 1817), styled Marquess of Blandford until 1758. He served as Lord Chamberlain between 1762 and 1763 and as Lord Privy Seal between 1763 and 1765. He is the great-great-great grandfather of Sir Winston Churchill.
Her Grandfather was John, Duke of Bedford.
Amelia married Henry Pitches Boyce on 22 September 1812 and she died on 30 January 1829.
She was buried at St Leonards, Streatham on 7th February in 1829